Refractive power and blood glucose changes: Studies in alloxan-induced and insulin-treated diabetic rabbits
Date
2015
Journal Title
Journal ISSN
Volume Title
Publisher
U. P.
Abstract
This study was carried out to determine the refractive power and blood glucose changes in alloxan-induced and insulin-treated diabetic rabbits. Eighteen healthy Dutch rabbits of both sexes weighing between 1.1kg and 1.9kg were used for this study. A 5% solution of alloxan monohydrate was administered intravenously to create a diabetic state. Refraction and blood glucose measurement was measured at approximately 5 days interval for 15 days before and after induction of diabetes by Streak retinoscopy. Results show a significant increase in hyperopia from + 1.49 D (+/- 0.59) to + 2.00 D (+/- 0.52) with increased blood glucose level after induction of diabetes. There was a significant positive correlation (P = 0.01) between hyperglycemic and hyperopic changes in the diabetic rabbits (r = +0.913, P<0.05). On the other hand, there was no significant correlation between insulin-induced blood glucose and refractive changes in insulin treated diabetic rabbits (r = +0.31, P > 0.05).
Description
This article contains tables and figures
Keywords
Refractive power, blood glucose, diabetes, insulin, hyperopia, Department of Optometry
Citation
Okorie, M. E., Nweke, I. N., Ahuama, O. C., Azuamah, Y. C. & Unekwe, P. C. (2015). Refractive power and blood glucose changes: Studies in alloxan-induced and insulin-treated diabetic rabbits. International Journal of Research 2(3), 728-736