Phytochemical screening and anti-malaria /typhoid fever activities of alstonia boonei (de wild) stem bark powder
Date
2013
Journal Title
Journal ISSN
Volume Title
Publisher
Global Science Book
Abstract
Anti-malaria/typhoid fever potential of graded doses of ethanolic and aqueous extracts of Alstonia boonei bark stem powder were investigated. The stem bark powder was also screened for the presence of some phytochemicals. The percentage chemo-suppressive activity (on early malaria infection in mice) of 100, 200 and 400 mg/kg body weight doses were found to be 81, 85 and 75%, respectively for the ethanolic extract and 56, 78 and 80%, respectively for the aqueous extract. This is substantial when compared to the 97% chemo-suppressive effect produced by 5 mg/kg body weight of chloroquine. The extracts did not produce any observable activity against Salmonella typhii. The phytochemical screening revealed the presence of saponin, flavonoids, terpenes, sterol and resins in the stem bark powder. These results further confirmed earlier reports that A. boonei possesses antimalarial activities.
Description
This article contains tables
Keywords
Anti-malaria, anti-typhoid, phytophemical, plasmodium berghei, salmonella typhi, Department of Biotechnology
Citation
Analogbu, E. A., Ezeji, E. U., Nwalozie, C. J. (2013). Phytochemical screening and anti-malaria /typhoid fever activities of alstonia boonei (de wild) stem bark powder. Medicinal and Aromatic Plant Science and Biotechnology, 7(1), 65-67