Synthesis, characterization and antimicrobial activities of quartnized long chain amides
Date
2021-09
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Federal University of Technology, Owerri
Abstract
The synthesis, characterization and antimicrobial activities of quarternized fatty amide having an amide functional group differing in the length of an alkylating chain (C8 andC12) were carried out. Their solubility in water, FTIR analysis of the starting materials, intermediate and final products were conducted and results showed the formation of amide functional group (-C=0 at 1643 cm-1, 1640 cm-1 and N-H at 3295 cm-1 and 3403 cm-1) which resulted from the removal of the ester group (-C=0 at 1740 cm-1, 1744cm-1and C-0 at 1170 cm-1) respectively. The mass spectrometric analysis of the final products were also conducted and results showed the presence of Molecular ion peak (M/Z = 334 and 390) which is the Molecular weight of the synthesized quats. Antimicrobial activity of the starting materials, the intermediate and the final products were evaluated and the results obtained show that N-benzyl-N, N-diethylamino ethyloctylamidium chloride is effective against Klebsiella spp. (20 mm) and Salmonella enterica (19 mm). Whereas Nbenzyl-N,N-iethylaminoethyllaurylamidium chloride were effective against Echerichiacoli (29 mm) and Salmonella enterica (22 mm) which is higher than the activity of the Thcontrol on the organisms mentioned above.
Description
This Thesis is for the award of Master of Science (M.Sc.) in Chemistry, Organic Chemistry Option
Keywords
Synthesis, characterization, antimicrobial, quarternized fatty, Department of Chemistry
Citation
Amafili, K. C. (2021). Synthesis, characterization and antimicrobial activities of quartnized long chain amides [Unpublished Master's Thesis]. Federal University of Technology, Owerri, Nigeria