Synthesis of a quaternary ammonium salt from epoxide and fatty amine and evaluation of its antimicrobial properties
| dc.contributor.author | Chukwunonyerem, Celestine C. | |
| dc.date.accessioned | 2026-03-21T09:31:27Z | |
| dc.date.available | 2026-03-21T09:31:27Z | |
| dc.date.issued | 2019-05 | |
| dc.description | This thesis is for the award of Master of Science (M.Sc.) in Organic Chemistry | |
| dc.description.abstract | Quaternary ammonium compound was synthesized from epoxy and fatty amine reaction. Fourier Transform Infrared(FTIR) spectrometric analysis of the starting materials, and the final product(N-benzyl-N,N-dioctyl-2-hydroxy-3 phenoxypropylammonium chloride) were conducted, and results showed a disappearance of sharp N-H peak of 2o amine, and appearance of broad O-H peak of alcohol in the spectrum of the final product. Mass spectrometric(MS)analysis of the final product was also conducted, and results showed the presence of molecular ion (M+ )peak withM/Z 483, which stands for the molecular weight of the compound.Antimicrobial activity of the starting materials, the intermediate, and the final product were evaluated, and results showed that only the Quaternary ammonium salt exhibited excellent antibacterial activity on a variety of bacteria including Gram-positive bacteria and Gram-negative bacteria with the following zones of inhibition: Salmonella Enteric (20 mm), Escherichia Coli (25 mm), Staphylococcus Aureus (15 mm), Lactobacillus Spp. (12 mm). | |
| dc.identifier.citation | Chukwunonyerem, C. C. (2019). Synthesis of a quaternary ammonium salt from epoxide and fatty amine and evaluation of its antimicrobial properties [Unpublished Master's Thesis]. Federal University of Technology, Owerri, Nigeria | |
| dc.identifier.uri | https://repository.futo.edu.ng/handle/20.500.14562/2431 | |
| dc.language.iso | en | |
| dc.publisher | Federal University of Technology, Owerri | |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Synthesis | |
| dc.subject | fourier transform infrared (FTIR) characterization | |
| dc.subject | mass spectrometric analysis | |
| dc.subject | antimicrobial analysis | |
| dc.subject | Department of Chemistry | |
| dc.title | Synthesis of a quaternary ammonium salt from epoxide and fatty amine and evaluation of its antimicrobial properties | |
| dc.type | Master’s Thesis |