Phytochemical analysis of aqueous methanolic extract of acanthospermum hispidium and its effect on biochemical and hematological indices in plasmodium falciparum infected rats
| dc.contributor.author | Azeez, T. O. | |
| dc.contributor.author | Banigo, A. T. | |
| dc.date.accessioned | 2024-11-14T13:53:49Z | |
| dc.date.available | 2024-11-14T13:53:49Z | |
| dc.date.issued | 2018-05 | |
| dc.description | This article contains table and figures | |
| dc.description.abstract | Haematological (Red blood cell ‘RBC’, packed cell volume ‘PCV’, white blood cell ‘WBC’ and platelet ‘PLA’) and biochemical (total protein, serum albumin and creatinine) parameters of rats treated with aqueous-methanolic extract of A. hispidum leaves on blood serum of rats infected with P. falciparum was investigated. The chemical composition was determined using gas chromatography and mass spectrometry (GC-MS). Biochemical and haematological parameters were examined using standard methods. The aqueous-methanolic extract of A. hispidum consist of Allyldimethyl-Formamide, Erythritol, Glycerin, Benzoylmethyl-3-hydroxy-5-nitro-2-indolinone, Silanol and Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester with composition of 13.578, 2.796, 56.72, 5.486, 1.415 and 10.005%, respectively. The increase in RBC, PCV, PLA and albumin with reduction in WBC and creatinine level compared to normal control when treated with aqueous – methanolic extract of A. hispidum leaves were obtained with reduced parasitaemia. Aqueous – methanolic A. hispidum leaves, at 400mg/kg for 72 hours proved to be the best for treatment of malaria parasite based on haematological and biochemical parameters assessed. | |
| dc.identifier.citation | Azeez, T.O & Banigo, A.T(2018)Phytochemical analysis of aqueous methanolic extract of acanthospermum hispidium and its effect on biochemical and hematological indices in plasmodium falciparum infected RatsAfr. J. Biomed. Res. Vol. 21 XXX- XXX | |
| dc.identifier.uri | https://repository.futo.edu.ng/handle/20.500.14562/1502 | |
| dc.language.iso | en | |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Acanthospermum hispidum | |
| dc.subject | plasmodium faciparum | |
| dc.subject | G-C-MS | |
| dc.subject | haematological | |
| dc.subject | biochemical parameters | |
| dc.subject | Department of Biomedical Engineering | |
| dc.title | Phytochemical analysis of aqueous methanolic extract of acanthospermum hispidium and its effect on biochemical and hematological indices in plasmodium falciparum infected rats | |
| dc.type | Article |