School of Egineering and Engineering Technology

Permanent URI for this collection

https://repository.futo.edu.ng/handle/20.500.14562/1239

Browse

Browsing School of Egineering and Engineering Technology by Subject "biochemical parameters"

Now showing 1 - 1 of 1
  • Thumbnail Image
    ItemOpen Access
    Phytochemical analysis of aqueous methanolic extract of acanthospermum hispidium and its effect on biochemical and hematological indices in plasmodium falciparum infected rats
    (2018-05) Azeez, T. O.; Banigo, A. T.
    Haematological (Red blood cell ‘RBC’, packed cell volume ‘PCV’, white blood cell ‘WBC’ and platelet ‘PLA’) and biochemical (total protein, serum albumin and creatinine) parameters of rats treated with aqueous-methanolic extract of A. hispidum leaves on blood serum of rats infected with P. falciparum was investigated. The chemical composition was determined using gas chromatography and mass spectrometry (GC-MS). Biochemical and haematological parameters were examined using standard methods. The aqueous-methanolic extract of A. hispidum consist of Allyldimethyl-Formamide, Erythritol, Glycerin, Benzoylmethyl-3-hydroxy-5-nitro-2-indolinone, Silanol and Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester with composition of 13.578, 2.796, 56.72, 5.486, 1.415 and 10.005%, respectively. The increase in RBC, PCV, PLA and albumin with reduction in WBC and creatinine level compared to normal control when treated with aqueous – methanolic extract of A. hispidum leaves were obtained with reduced parasitaemia. Aqueous – methanolic A. hispidum leaves, at 400mg/kg for 72 hours proved to be the best for treatment of malaria parasite based on haematological and biochemical parameters assessed.