Browsing by Author "Unekwe, P. C."

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    Refractive power and blood glucose changes: Studies in alloxan-induced and insulin-treated diabetic rabbits
    (U. P., 2015) Okorie, M. E.; Nweke, I. N.; Ahuama, O. C.; Azuamah, Y. C.; Unekwe, P. C.
    This study was carried out to determine the refractive power and blood glucose changes in alloxan-induced and insulin-treated diabetic rabbits. Eighteen healthy Dutch rabbits of both sexes weighing between 1.1kg and 1.9kg were used for this study. A 5% solution of alloxan monohydrate was administered intravenously to create a diabetic state. Refraction and blood glucose measurement was measured at approximately 5 days interval for 15 days before and after induction of diabetes by Streak retinoscopy. Results show a significant increase in hyperopia from + 1.49 D (+/- 0.59) to + 2.00 D (+/- 0.52) with increased blood glucose level after induction of diabetes. There was a significant positive correlation (P = 0.01) between hyperglycemic and hyperopic changes in the diabetic rabbits (r = +0.913, P<0.05). On the other hand, there was no significant correlation between insulin-induced blood glucose and refractive changes in insulin treated diabetic rabbits (r = +0.31, P > 0.05).