The efficacy of antioxidant (Vitamin C) in the treatment and management of malaria
| dc.contributor.author | Mgbemena, Ifeyinwa Celestina | |
| dc.date.accessioned | 2025-03-27T11:21:02Z | |
| dc.date.available | 2025-03-27T11:21:02Z | |
| dc.date.issued | 2020-04-30 | |
| dc.description | The article contains tables and figures | |
| dc.description.abstract | The study examines the effects of Vitamin C on malaria parasitamae and the biochemical parameters which is an indicative of the liver function. Twenty wistar Albino rats were by average weight of 100 – 250g divided into 5 groups, Groups 1) served as normal control(NC), group 2 as experimental groups (PC), (Group 3 & 4 ) served as Vitamin C and group 5 served as Artesunate control. All the groups were inoculated with a chloroquine-sensitivestrain of Plasmodium berghei NK-65 following the administration of vitamin C and artesunate drugs. The Animals were treated for 4 days after 24 hours, post infection with P. berghei. Parasitemia levels were assessed by examining Giemsa-stained thin blood smears from each animal via an optical microscope on days 4 and 7. Blood samples collected from the animals via cardiac puncture with the aid of a capillary tube, was allowed to clot for 45 min at room temperature. Serum was separated by centrifugation at 6,000rpm for 15 min and analyzed for liver function parameters. There was a significant suppression (P<0.05) in total parasite count (205.00 & 137.00 and 242.25 & 157.00) on days 4 and 7 when compared with the other controls (300.75 & 403.25), as well as a reduction in liver function parameters with Vitamin C at 15mg & 7.5mg. This study however shows that vitamin C administration to P.berghei infected rats resulted in reducing parasite count as well as reduced malaria related alteration of liver function markers. | |
| dc.identifier.citation | Mgbemena, I. C. (2020). The efficacy of antioxidant (Vitamin C) in the treatment and management of malaria. Scholars Academic Journal of Pharmacy, 9(4), 148 - 154 | |
| dc.identifier.doi | 10.36347/sajp.2020.v09i04.003 | |
| dc.identifier.issn | p-2347-9531 | |
| dc.identifier.issn | e-2320-4206 | |
| dc.identifier.uri | https://repository.futo.edu.ng/handle/20.500.14562/1713 | |
| dc.language.iso | en | |
| dc.publisher | SAS Publishers, India | |
| dc.rights | Attribution-NonCommercial-ShareAlike 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-sa/4.0/ | |
| dc.subject | Vitamin C | |
| dc.subject | plasmodium berghei | |
| dc.subject | malaria | |
| dc.subject | parasitemia | |
| dc.subject | antioxidant. | |
| dc.subject | Department of Biotechnology | |
| dc.title | The efficacy of antioxidant (Vitamin C) in the treatment and management of malaria | |
| dc.type | Article |