Antibacterial activity and identification of metabolites from the semi-purified fraction of chrysophyllum albidum leaf (African Star Apple)

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dc.contributor.authorAzih, Ifeanyi
dc.contributor.authorIjezie, Magnus
dc.contributor.authorUgariogu, Sylvester N.
dc.contributor.authorAkalezi, Christogonus O.
dc.date.accessioned2025-01-28T12:20:45Z
dc.date.available2025-01-28T12:20:45Z
dc.date.issued2020
dc.descriptionThis article contains tables and figures
dc.description.abstractThe medicinal uses of natural products especially medicinal plants have increased tremendously due to the multidrug resistance of some microorganisms and due to the availability and affordability of these plants. This study was aimed at the identification of metabolites from the fractions of Chrysophyllum albidium and their antibacterial activity. The phytochemical analysis and antibacterial analysis were done using standard methods; Harborne and Agar-disc diffusion methods, respectively. The metabolite identification was done using infra-red (IR) and gas chromatography – mass spectrometry (GC-MS). The preliminary result of the antibacterbial screening showed that the neutral metabolite possessed the highest antibacterial activity and was then chosen for the IR and GC-MS study and purified using preparative thin layer chromatography. Various fractions were obtained from the chromatographic purification and in particular N3 fraction demonstrated the highest antibacterial activity against the test microbes with the zones of inhibition indicated against the test organism as follows: Streptococcus spp (18 mm), Staphylococcus aureus (20 mm), Salmonella typhi (25 mm), Escherichia coli (20 mm) and no inhibition zone against Enterobacter cloacae. The results confirm that the plant has some antibacterial activity.
dc.identifier.citationAzih, I., Ijezie, M., Ugariogu, S. N. & Akalezi, C. O. (2020). Antibacterial activity and identification of metabolites from the semi-purified fraction of chrysophyllum albidum leaf (African Star Apple). Tropical Journal of Natural Product Research, 4(7), 262-269
dc.identifier.issnp-2616-0684
dc.identifier.issne-2616-0692
dc.identifier.urihttps://repository.futo.edu.ng/handle/20.500.14562/1598
dc.language.isoen
dc.publisherU. P.
dc.relation.ispartofseriesISSN
dc.relation.ispartofseriesISSN
dc.rightsAttribution-NonCommercial-ShareAlike 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/
dc.subjectChrysophyllum albidium
dc.subjectmetabolites identification
dc.subjectphytochemicals
dc.subjectantibacterial.
dc.subjectDepartment of Chemistry
dc.titleAntibacterial activity and identification of metabolites from the semi-purified fraction of chrysophyllum albidum leaf (African Star Apple)
dc.typeArticle

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