Gas chromatography-spectrophotometric (GC- MS) studies on therapeutic potentials of costus afer ker gawl leaves
Date
2018
Journal Title
Journal ISSN
Volume Title
Publisher
U. P.
Abstract
The ethanol leaf extract of Costus afer was subjected to qualitative phytochemical screening, column chromatography and GC-MS analysis to ascertain the compounds that exhibit anti-inflammatory and anti-oxidant properties as claimed by herbalists and traditionalists. The presence of Flavonoids, Saponins, Steroids, Terpenoids and Anthraquinones were indicated in the phytochemical screening. Eluent fractions from the moderately polar solvent of the column chromatography generated Gas Chromatogram that had 6 prominent peaks indicated that the prevailing compounds were oxirane hexadecyl (4.09%), n-Hexadecanoic acid(3.68%), 9-octadecenoic acid (z)- methyl ester(3.08%), 6-octadecenoic acid (z)- (13.49%) and two pentacyclic compounds identified as Cycloursan-3-ol, acetate (36.17%) and lupenone (39.50%). The two pentacyclic compounds confirmed the presence of steroids and validates the use of C.afer leaf for anti inflammatory therapy and as an antidote for acute toxi.
Description
This article contain figures and tables
Keywords
Anti-inflammatory, Anti-oxidant, Costus afer, GC-MS, lupenone, Department of Chemistry
Citation
Ogukwe, C. E., Akalezi, C. O., Anukam, B. N., Idika, I. D. & Awosu, E. A. ( 2018 ). Gas chromatography-spectrophotometric (GC-MS) studies on therapautic potentials of costus afer ker gawl leaves. World Journal of Pharmaceutical Research, 7( 9), 78 - 88