Browsing by Author "Esseh, Jane Nnenna"

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    Chemical and toxicological evaluations of boiled Hemidactylus frenatus and Scolopendridae cataracta solutions in albino rats
    (Federal University of Technology, Owerri, 2024-07) Esseh, Jane Nnenna
    This study evaluated the chemical profile and toxicological potential of Hemidacylus frenatus (wall gecko) and Scolopendridae cataracta (centipede) boiled solution in albino rats. Thirty-five (35) male albino rats that weighed 96.00 ± 0.06 g and aged 9 to 10 weeks were divided into seven groups: group 1 received feed and water only and served as the control group, group 2 received 10 ml/kg body weight (b.w) of boiled degutted wall gecko solution (BDWGS), group 3 received 20 ml/kg b.w of BDWGS, group 4 received 10 ml/kg b.w of boiled whole wall gecko solution (BWWGS), group 5 received 20 ml/kg b.w BWWGS, group 6 received 10 ml/kg b.w of boiled centipede solution (BCS) and group 7 received 20 ml/kg b.w BCS; for 28 days through oral route. The GC-MS analyses of the boiled solutions revealed the presence of benzenamine, methenamine, 1H-imidazole, halcinonide, acetamide, cyclohexane, colchiceine, ethyl oxamate and N-(4-Aminobutyl) aziridine in them. The results of the acute toxicity (LD50) of the boiled centipede and wall gecko solutions showed no mortality at the study level. There were significant (p<0.05) increases in blood urea, creatinine, sodium ion, chloride ion concentrations and ALP, ALT and AST activities and a decrease in bicarbonate ion concentration following administration of BWWGS and BCS. Total and direct bilirubin concentrations increased in all treatment groups while total protein, albumin and globulin concentrations reduced in BWWGS and BCS groups when compared to control group. Alterations in renal and hepatic functional indices were confirmed in histopathological study of liver and kidney tissues; ostensibly caused by the toxic chemical compositions of the treatment solutions. In conclusion, the boiled wall gecko and centipede solutions were toxic to the liver and kidneys of the rats.