Browsing by Author "Ekeke, Kelechi Light"

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    Effects of sesamum indicum compounded diet on alloxan-induced diabetic rats
    (Federal University of Technology, Owerri, 2023-08) Ekeke, Kelechi Light
    The purpose of this study was to assess the effects of Sesamum indicum compounded diet on alloxan induced diabetic rats. For the study, which lasted 21 days, 36 male albino rats were divided into nine groups of four rats each (Grp 1 Normal control, Grp 2 Diabetic control, Grp 3 standard drug-Glibenclamide treated, Grp 4, 5, and 6 diabetic rats fed with 15%, 30%, and 60% compounded diet respectively, and Grp 7, 8 and 9 rats fed with 15%, 30%, and 60% compounded diet respectively for 14 days prior to diabetes induction). A single intraperitoneal dosage of freshly produced alloxan (140 mg/kg body weight) was used to induce diabetes. Accheck Glucometer was used to measure blood sugar levels. Utilizing conventional spectrophotometric techniques, values for lipid, kidney, and liver function were assessed. When compared to the diabetic control at the conclusion of the study, the blood glucose levels of groups 4, 5, and 6 fed on 15%, 30%, and 60% compounded diets, respectively, were reduced below 200. After two weeks of feeding on the compounded diet, group 7, 8, and 9 were induced. It was found that their blood glucose levels were still < 200. The trend in Lipid profile (CHOL, TRIG, and LDL) parameters and blood glucose were similar, with a significant difference of P<0.05, although the HDL, which was low in untreated diabetics, increased in the groups fed the compound diet. Comparing groups fed the compounded diet to the diabetic control group, the level of Kidney parameters showed a decrease at a significant difference of P<0.05. The parameters of Liver function showed the same pattern. From the relative organ weight result, the groups fed with the compounded diet showed a weight decrease in the Liver and Kidney while the Pancreas increased compared to the diabetic group that has the opposite. There is no significant difference between the groups fed with the diet before induction of diabetes and the group induced before feeding with the diet. The result of this research proves that the compounded diet has both Ameliorative and Protective properties against diabetes mellitus.