Browsing by Author "Banigo, A. T."

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    Nanobiosensors: Applications in biomedical technology
    (IOP Publishing, 2020) Banigo, A. T.; Azeez, T. O.; Ejeta, K. O.; Lateef, A.; Ajuogu, E.
    Biosensor devices are composed of bioreceptor, transducer and detector that detect and aid in measuring parameters of some primary metabolites, immunological molecules and many more materials. These devices are of various types including piezoelectric which exhibit high efficiency based on sensitivity, response time, selectivity and linearity. Currently, newly developed nanobiosensors help in transduction and are employed to sense biomolecules bearing high sensitivity. Nanobiosensors also could be homogeneous or heterogeneous in nature and equally function in sensing mechanism of the biosensing technology. Thus, different nanobiosensors are greatly utilized to reduce poison in products, disease diagnostics and in many biomedical applications. Based on all these factors and the positive impact of using these devices; nanobiosensor types, applications, challenges and preferred solution in biomedical technology were considered and discussed in this work.
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    Phytochemical analysis of aqueous methanolic extract of acanthospermum hispidium and its effect on biochemical and hematological indices in plasmodium falciparum infected rats
    (2018-05) Azeez, T. O.; Banigo, A. T.
    Haematological (Red blood cell ‘RBC’, packed cell volume ‘PCV’, white blood cell ‘WBC’ and platelet ‘PLA’) and biochemical (total protein, serum albumin and creatinine) parameters of rats treated with aqueous-methanolic extract of A. hispidum leaves on blood serum of rats infected with P. falciparum was investigated. The chemical composition was determined using gas chromatography and mass spectrometry (GC-MS). Biochemical and haematological parameters were examined using standard methods. The aqueous-methanolic extract of A. hispidum consist of Allyldimethyl-Formamide, Erythritol, Glycerin, Benzoylmethyl-3-hydroxy-5-nitro-2-indolinone, Silanol and Hexadecanoic acid, 1-(hydroxymethyl)-1,2-ethanediyl ester with composition of 13.578, 2.796, 56.72, 5.486, 1.415 and 10.005%, respectively. The increase in RBC, PCV, PLA and albumin with reduction in WBC and creatinine level compared to normal control when treated with aqueous – methanolic extract of A. hispidum leaves were obtained with reduced parasitaemia. Aqueous – methanolic A. hispidum leaves, at 400mg/kg for 72 hours proved to be the best for treatment of malaria parasite based on haematological and biochemical parameters assessed.