Browsing by Author "Anyado-Nwadike, S. O."

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    Antimicrobial activity of the leaf extracts of Moringa oleifera and Jatropha curcas on pathogenic bacteria
    (International Formulae Group, 2013-02) Okorondu, S. I.; Akujobi, C. O.; Okorondu, J. N.; Anyado-Nwadike, S. O.
    This study evaluates the antimicrobial activity of the leaf extracts of Moringa oleifera and Jatropha curcas against Staphylococcus aureus and Escherichia coli. Different concentrations of the extracts were subjected to these organisms in which Moringa oleifera showed a higher zone of inhibition on Staphylococcus aureus (2.8 cm) while on E. coli (2.4 cm) while Jatropha curcas showed a higher zone of inhibition on E. coli (2.6 cm) while on S. aureus (1.80 cm). The minimum inhibitory concentration (MIC) of Moringa oleifera extract on E. coli and S. aureus were 0.250 mg/ml and 0.125 mg/ml respectively while MIC of Jatropha curcas extract on test organisms was 0.125 mg/ml. The quantitative phytochemical screening in g/kg revealed the presence of flavonoid 36 and 21, alkaloids 92 and 39, tannins 7.4 and 5.6, saponins 115.0 and 53.5, cyanogenic glycosides 8.4 and 14.5 for M. oleifera and J. curcas respectively. The observed antimicrobial properties could be due to the presence of these bioactive compounds and further substantiates the use of Moringa oleifera and Jatropha curcas leaf extracts in medicine. The extracts in correct doses can successfully be used in vivo to inhibit and eventually kill the test bacteria used in this study.
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    Prevalence and antibiotic sensitivity profile of urinary tract infection pathogens among pregnant and non pregnant women
    (International Formulae Group, 2013-08) Okorondu, S. I.; Akujobi, C. O.; Nnadi, C. B.; Anyado-Nwadike, S. O.; Okorondu, M. M. O.
    The prevalence and antibiotic sensitivity profile of urinary tract infection isolates from 100 pregnant women attending antenatal clinic in Owerri General Hospital, Nigeria was assessed. The prevalence of UTI isolates from the pregnant women was compared with that in non-pregnant women. The organisms isolated include: Escherichia coli, Staphylococcus aureus, Coagulase negative Staphylococcus, Klebsiella spp, Pseudomonas spp, Proteus spp and Streptococcus spp. Antibiotic sensitivity pattern of the isolates were also determined using disk diffusion test. One hundred (100) women were tested; 40% had bacteriuria as against 31% in non-pregnant women. The most sensitive isolate was E. coli, while the least was Streptococcus spp. The most effective antibiotics were Gentamycin, Tarivid and Ciprofloxacin, while the least occurred with Chloramphenicol, Ampicillin, Septrin, Ampiclox. Improvement on personal hygiene and diagnostic screening and treatment will help to reduce the prevalence of bacteriuria in pregnancy. There is also the need for regular antibiotic survey as this will ensure up to date information on the usefulness of the various antibiotics to treat infection thereby avoiding drug resistance as a result of continuous usage of drugs that are not sensitive to some microorganisms.