Okorie, M. E.Nweke, I. N.Ahuama, O. C.Azuamah, Y. C.Unekwe, P. C.2026-06-042026-06-042015Okorie, M. E., Nweke, I. N., Ahuama, O. C., Azuamah, Y. C. & Unekwe, P. C. (2015). Refractive power and blood glucose changes: Studies in alloxan-induced and insulin-treated diabetic rabbits. International Journal of Research 2(3), 728-736e-2348-6848p-2348-795Xhttp://internationaljournalofresearch.org/https://repository.futo.edu.ng/handle/20.500.14562/2804This article contains tables and figuresThis study was carried out to determine the refractive power and blood glucose changes in alloxan-induced and insulin-treated diabetic rabbits. Eighteen healthy Dutch rabbits of both sexes weighing between 1.1kg and 1.9kg were used for this study. A 5% solution of alloxan monohydrate was administered intravenously to create a diabetic state. Refraction and blood glucose measurement was measured at approximately 5 days interval for 15 days before and after induction of diabetes by Streak retinoscopy. Results show a significant increase in hyperopia from + 1.49 D (+/- 0.59) to + 2.00 D (+/- 0.52) with increased blood glucose level after induction of diabetes. There was a significant positive correlation (P = 0.01) between hyperglycemic and hyperopic changes in the diabetic rabbits (r = +0.913, P<0.05). On the other hand, there was no significant correlation between insulin-induced blood glucose and refractive changes in insulin treated diabetic rabbits (r = +0.31, P > 0.05).enAttribution-NonCommercial-ShareAlike 4.0 InternationalRefractive powerblood glucosediabetesinsulinhyperopiaDepartment of OptometryArticle